I've stumbled across a few where the central struggle is against a life deity or a figure with that kind of creative power, and it's always such an interesting dynamic because it flips the usual 'fight the evil death god' script on its head. One that immediately comes to mind is 'The Invisible Life of Addie LaRue'. It's not a traditional 'god of life' in a fantasy pantheon sense, but the entity known as Luc is a god of, well, living moments, memory, and the essence of existence itself. The conflict is deeply personal and philosophical—Addie isn't trying to destroy him with a sword; she's trying to outlive his curse, to carve a life for herself that he can't claim. It’ s less about a battle and more about a protracted, centuries-long act of defiance against a being who defines the very terms of her existence.
Then there's a much more direct, epic fantasy take in N.K. Jemisin's 'The Broken Earth' trilogy. You've got the stone eaters and the Guardians, but the overarching force of Father Earth himself is a kind of wrathful, living planetary consciousness. The struggle isn't to kill it, because it is the world, but to negotiate, to survive its systematic attempts to purge humanity. The conflict is geological, slow, and utterly brutal. It redefines what fighting a 'life' force means—it's not a person you duel, it's the ground shaking beneath your feet.
On a different note, I remember a weird little indie fantasy series I found on RoyalRoad called 'Beware of Chicken'. It sounds silly, and it is, but the core joke has a serious underpinning: the main character flees a world governed by brutal cultivation rules that feel like they're enforced by a cosmic, life-siphoning system. His conflict is with the very ethos of a world that sees life as a resource to be consumed for power. By choosing to just farm peacefully, he's engaging in a quiet, profound rebellion against that entire life-as-commodity framework. It’ s a conflict of philosophies more than fists, and the 'god of life' in this case is the impersonal, demanding system of the universe itself.