For the Thor/Loki ship on AO3, 'domestic fluff' gets a weirdly large amount of traction, honestly more than I would've guessed. It's not all thunder and angst; you'd be surprised how many fics are just about them bickering over who does the dishes in New Asgard or adopting a weird alien pet. That craving for normalcy after all the universe-ending drama makes a lot of sense, psychologically.
Then there's the 'post-Infinity War resurrection' or 'time travel fix-it' niche, which is absolutely massive. It's a direct response to the films, obviously, where writers just refuse to accept the canon outcomes. You get these intricately plotted fics where Loki uses his magic to cheat death, or Thor goes back and changes everything. The appeal is that power fantasy of fixing the unfixable, of giving them both a happier ending.
A less discussed but pervasive theme is 'magic exhaustion' or 'injury recovery'. Loki collapses from overextending his seiðr, and Thor has to care for him, leading to these vulnerable, quiet moments where all their centuries of complicated history simmer under the surface. It flips their dynamic, making the usually unshakeable Thor the protector and the perpetually scheming Loki completely defenseless. That shift is catnip for character study fans.
And you can't ignore the 'frost giant biology' deep dives, which often tie into the 'arranged marriage' or 'political alliance' trope. Writers really explore the cultural and physiological differences, using Jotunheim world-building as a backdrop for forced proximity and eventual understanding. It's a great vehicle for exploring prejudice, acceptance, and, of course, smut with a fantasy twist.